By Jenny Wells
Macrophages from an African spiny mouse promote tissue regeneration.
A team of University of Kentucky researchers has discovered that macrophages, a type of immune cell that clears debris at injury sites during normal wound healing and helps produce scar tissue, are required for complex tissue regeneration in mammals. Their findings, published today in eLife, shed light on how immune cells might be harnessed to someday help stimulate tissue regeneration in humans.
“With few examples to study, we know very little about how regeneration works in mammals; most of what we know about organ regeneration comes from studying invertebrates or from research in amphibians and fish,” said Ashley Seifert, senior author of the study and assistant professor of