Demand for small diameter vascular grafts is growing. Main limitations of these grafts include induced thrombotic events, lack of in-situ endothelialization, intimal hyperplasia and poor mechanical properties which impair the graft patency rate in long term applications. Most of the used antithrombotic modification methods usually conflict with formation of endothelial cell monolayer on the grafts. Here, we synthesized a novel biodegradable elastic poly (ester ether urethane urea) (PEEUU) using poly (ethylene glycol) (PEG) and poly (diethylene glycol adipate) (PDEGA) as soft segments.To improve hemocompatibility, synthesized PEEUU was blended with ferulic acid (FA). Scanning electron microscopy (SEM), water contact angle (CA) measurement, and tensile test were utilized to characterize the scaffolds. The PEEUU and PEEUU-FA scaffolds revealed appropriate mechanical properties, with tensile strengths and strains similar to coronary artery. In vitro assay demonstrated that the release of ferulic acid from the scaffold is in a sustained manner. The hemocompatibility tests indicated that PEEUU-FA samples induced lower platelet adhesion compared to the PEEUU sample. A reduction in hemolysis and fibrinogen adsorption was detected on PEEUU-FA sample. Cell studies showed that PEEUU-FA supported adhesion, spreading and proliferation of endothelial cells. The cells maintained endothelial cell phenotype through the expression of endothelial cell marker (CD31). The results revealed that the new PEEUU modified with ferulic acid can be considered as a promising candidate for vascular application with enhanced blood compatibility and vascular cell-compatibility.