The choice of ionization method depends on the properties of the sample.
The choice of ionization method depends on the properties of the sample.
Small Molecules
Small molecules may be suitable for MALDI if they are readily ionizable. In positive ion mode, singly-charged ions produced by addition of H+ or Na+ are most common.
Polymers
Organonometallics/Polyconjugated Aromatics
MALDI also works well for highly conjugated aromatic systems and some organometallic compounds. Ions may be produced by proton attachment or photoionization.
